What it is: 16-amino-acid peptide. Under metabolic stress it moves into the nucleus and rewires gene expression to restore cellular balance.

Researched Effects:

• Aging MOTS-c levels drop with age. Restoring them activates protective mitochondrial genes and helps reverse age-related metabolic decline.
• Cardiovascular Health Protects the heart from pathological remodeling and heart-failure progression. Mimics many benefits of aerobic exercise.
• Insulin Resistance & Metabolic Health Dramatically boosts skeletal-muscle insulin sensitivity. Prevents diet-induced obesity and hyperinsulinemia. In aged mice it fully restores youthful glucose handling in just 7 days.
• Inflammation MOTS-c lowers pro-inflammatory cytokines (the chemicals that cause swelling and pain) while raising anti-inflammatory ones, and it also reduces pain signals.

For research use only. Not for human consumption.

Research source: Zheng, Y., Wei, Z., & Wang, T. (2023). MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in Endocrinology, 14, 1120533. https://doi.org/10.3389/fendo.2023.1120533